Mix the base: In a medium bowl, stir together the Greek yogurt, mozzarella, parmesan, garlic powder, oregano, and red pepper flakes until well combined.
Layer the dip: Spread the Greek yogurt mixture into a serving dish or oven-safe skillet.
Add sauce & toppings: Spread the pizza sauce evenly on top, then sprinkle with chopped pepperoni and a little extra mozzarella if desired.
Warm it up (optional): If you prefer a warm dip, bake at 375°F for 10-12 minutes or microwave for 1-2 minutes until melty.